Pathophysiology of bone metastases.

  title={Pathophysiology of bone metastases.},
  author={James R Berenson and Lakshmi Rajdev and Michael F. Broder},
  journal={Cancer biology & therapy},
  volume={5 9},
Normal bone remodeling maintains an appropriate balance between the action of osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells). Skeletal malignancies, including bone metastases, disrupt the OPG-RANKL-RANK signal transduction pathway and promote enhanced osteoclast formation, thereby accelerating bone resorption and inducing bone loss. This osteolysis in turn leads to the release of bone-derived growth factors, contributing to a "vicious cycle" in which interactions… CONTINUE READING


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