Pathophysiology of bleeding and clotting in the cardiac surgery patient: from vascular endothelium to circulatory assist device surface.

@article{Achneck2010PathophysiologyOB,
  title={Pathophysiology of bleeding and clotting in the cardiac surgery patient: from vascular endothelium to circulatory assist device surface.},
  author={Hardean E. Achneck and Bantayehu Sileshi and Amar Parikh and Carmelo A. Milano and Ian J. Welsby and Jeffrey Harold Lawson},
  journal={Circulation},
  year={2010},
  volume={122 20},
  pages={2068-77}
}
Clinicians are faced with the challenge of navigating the precarious balance between bleeding and clotting. Bleeding disorders or failure to obtain adequate hemostasis during surgery may lead to severe hemorrhage. However, if thrombotic complications occur (eg, thromboembolic stroke), they may be far more difficult to treat. To achieve a stable equilibrium between bleeding and clotting, the treating physician should have a fundamental understanding of coagulation biology. In this article, we… CONTINUE READING