Pathophysiology of anaphylaxis

@article{Khan2011PathophysiologyOA,
  title={Pathophysiology of anaphylaxis},
  author={B. Q. Khan and S. Kemp},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2011},
  volume={11},
  pages={319–325}
}
  • B. Q. Khan, S. Kemp
  • Published 2011
  • Medicine
  • Current Opinion in Allergy and Clinical Immunology
Purpose of review This review aims to provide an overview of the evolving understanding of the pathophysiology of anaphylaxis. Recent findings Immunopathologic mechanisms of anaphylaxis have traditionally focused on the IgE-dependent and IgE-independent release of mediators from mast cells and basophils. There are accumulating data supporting the significance of alternative pathways of anaphylaxis. Increasing attention has also focused on the internal compensatory mechanisms activated in… Expand

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Background Anaphylaxis is a life‐threatening syndrome resulting from the sudden release of mast cell‐ and basophil‐derived mediators into the circulation. However, pathological evidence of theExpand
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