Pathophysiology of acute brain dysfunction: what's the cause of all this confusion?

  title={Pathophysiology of acute brain dysfunction: what's the cause of all this confusion?},
  author={C. Hughes and M. Patel and P. Pandharipande},
  journal={Current Opinion in Critical Care},
  • C. Hughes, M. Patel, P. Pandharipande
  • Published 2012
  • Medicine
  • Current Opinion in Critical Care
  • Purpose of reviewTo survey the recent medical literature examining the pathophysiology of acute brain dysfunction (delirium and coma) in the ICU. Recent findingsClinical risk factors for brain dysfunction in the ICU continue to be elucidated and prediction models developed. Multiple studies have identified sedatives, especially benzodiazepines, as modifiable risk factors for delirium. Imaging studies examining global brain disorders have demonstrated white matter lesions and brain atrophy to be… CONTINUE READING
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