Pathophysiology of Severe Ischemic Myocardial Injury

  title={Pathophysiology of Severe Ischemic Myocardial Injury},
  author={Hans Michael Piper and Ger J. van der Vusse and Marc van Bilsen},
  booktitle={Developments in Cardiovascular Medicine},
Like all living cells, myocytes are enclosed in a plasma membrane (plasmalemma) which is composed of phospholipids, cholesterol and proteins. The phospholipids form a lipid bilayer. Disruption of the plasmalemma has been postulated to be a proximate cause of irreversible injury inflicted on the cell by ischemia and/or reperfusion. Depletion of phospholipids, by either enhanced enzymatic hydrolysis or impaired resynthesis of the phospholipid molecules, has been proposed as a mechanism underlying… CONTINUE READING


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