Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

Abstract

Huntington's disease (HD) is a progressive, fatal neurological condition caused by an expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date, there is no cure but great strides have been made to understand pathophysiological mechanisms. In particular, genetic animal models of HD have been instrumental in elucidating the… (More)
DOI: 10.1016/j.neuroscience.2011.08.052

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