Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy

  title={Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy},
  author={H. Starobova and I. Vetter},
  journal={Frontiers in Molecular Neuroscience},
  • H. Starobova, I. Vetter
  • Published 2017
  • Medicine
  • Frontiers in Molecular Neuroscience
  • Chemotherapy-induced neuropathy is a common, dose-dependent adverse effect of several antineoplastics. It can lead to detrimental dose reductions and discontinuation of treatment, and severely affects the quality of life of cancer survivors. Clinically, chemotherapy-induced peripheral neuropathy presents as deficits in sensory, motor, and autonomic function which develop in a glove and stocking distribution due to preferential effects on longer axons. The pathophysiological processes are multi… CONTINUE READING
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