Pathophysiology and treatment of painful diabetic neuropathy of the lower extremity.


BACKGROUND Symptomatic peripheral neuropathy is the most common complication of diabetes mellitus, affecting up to 62% of Americans with diabetes. METHODS We reviewed the literature using the National Library of Medicine's MEDLINE search service. In total, we reviewed 54 articles. RESULTS Hyperglycemia leads to increased activity in the polyol pathway… (More)


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