Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives
@article{Stevens2013PathophysiologyAP, title={Pathophysiology and pharmacotherapy of gastroparesis: current and future perspectives}, author={Julie E. Stevens and Karen L. Jones and Christopher K. Rayner and Michael Horowitz}, journal={Expert Opinion on Pharmacotherapy}, year={2013}, volume={14}, pages={1171 - 1186} }
Introduction: Gastroparesis is an important clinical disorder characterised by delayed gastric emptying in the absence of mechanical outlet obstruction. Idiopathic, diabetes and postsurgical causes represent the most common aetiologies. The condition commonly manifests as upper gastrointestinal symptoms, including nausea, vomiting, postprandial fullness, early satiety, abdominal pain and bloating. Areas covered: This paper provides a review of the prevalence, pathophysiology and clinical…
67 Citations
Safety of treatment for gastroparesis
- MedicineExpert opinion on drug safety
- 2016
An overview of the safety of the available pharmacological therapies utilized in the treatment of gastroparetic symptoms specifically addressing thesafety of prokinetics, antiemetics, sensory neuromodulators and pain modifying agents is provided.
Pathophysiology, Aetiology and Treatment of Gastroparesis
- MedicineDigestive Diseases and Sciences
- 2020
Novel prokinetic agents have shown initial promise in clinical trials, and new endoscopic techniques such as gastric per-oral endoscopic myotomy are emerging that may provide an option in refractory gastroparesis with the adage of reduced morbidity compared to surgical treatments.
[Gastroparesis - causes, diagnosis and treatment].
- MedicineTidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- 2016
The causes, assessment and treatment options of gastroparesis are elucidate, and the condition may have significant consequences for patients, entailing reduced quality of life, reduced workforce participation and a considerable need for health assistance.
Gastroparesis in children
- MedicineCurrent opinion in pediatrics
- 2015
Treatment of gastroparesis consists of symptomatic relief with medication to counteract the nausea, emesis, pain, bloating, gastroesophageal reflux, early satiety, and improve gastric emptying.
Pathophysiology and Treatment of Gastrointestinal Motility Disorders in the Acutely Ill.
- Medicine, BiologyNutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
- 2019
There is a lack of evidence to guide drug therapy of ileus, but neither erythromycin nor metoclopramide appear to have a role, and several drugs, including ghrelin agonist, highly selective 5-hydroxytryptamine receptor agonists, and opiate antagonists are being studied in clinical trials.
Investigational drug therapies for the treatment of gastroparesis
- MedicineExpert opinion on investigational drugs
- 2017
It is also important to note that different upper gastrointestinal disorders (gastroparesis, chronic unexplained nausea and vomiting, functional dyspepsia) are difficult to distinguish apart, suggesting wider therapeutic opportunity.
Current and Emerging Medical Therapies for Gastroparesis
- MedicineCurrent Treatment Options in Gastroenterology
- 2015
This chapter will review current treatment options, upcoming promising medications, and some of the hurdles in advancing the field forward in gastroparesis.
Gastrointestinal involvement in systemic sclerosis: diagnosis and management
- MedicineCurrent opinion in rheumatology
- 2018
This review provides important updates in systemic sclerosis (SSc)-related gastrointestinal disease, with a particular focus on the diagnosis and management of dysmotility.
Rectal Sensitivity in Diabetes Patients with Symptoms of Gastroparesis
- MedicineJournal of diabetes research
- 2014
In patients with signs and symptoms of diabetic gastroparesis, rectal sensitivity was reduced, and heart rate variability was impaired, suggesting diabetic autonomic neuropathy as a diffuse disorder.
Prokinetics in Treatment of Gastric Motility Disorders
- Medicine
- 2017
Congenital abnormalities, postsurgical and medical conditions such as gastroparesis, gastric arrhythmias, myenteric neuropathies, functional dyspepsia and Parkinson’s diseases to name a few have the…
References
SHOWING 1-10 OF 141 REFERENCES
Management of gastroparesis
- MedicineExpert review of gastroenterology & hepatology
- 2008
Management of idiopathic gastroparesis relies primarily on therapies that accelerate gastric emptying or reduce vomiting, although endoscopic or surgical options are available for refractory cases.
Pathophysiology and management of gastroparesis
- MedicineExpert review of gastroenterology & hepatology
- 2009
Gastroparesis is characterized by upper gastrointestinal symptoms associated with delayed gastric emptying, without mechanical obstruction, and probably represents a major cause of poor glycemic control in diabetics.
Bloating in Gastroparesis: Severity, Impact, and Associated Factors
- MedicineThe American Journal of Gastroenterology
- 2011
Findings provide insight into this underappreciated symptom of gastroparesis and suggest antiemetics, probiotics, and antidepressants with significant norepinephrine reuptake inhibitor activity may affect reports of bloating.
Phenotypic switching in diabetic gastroparesis: mechanism directs therapy.
- MedicineGastroenterology
- 2011
It is now quite clear that not all of the symptoms reported by patients with diabetic gastroparesis are due to delayed gastric emptying, and patient symptoms may switch over time, suggesting that different pathophysiologic mechanisms may predominate at different times.
Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanechol.
- MedicineGastroenterology
- 1980
Effect of metoclopramide in diabetic gastroparesis.
- MedicineJournal of clinical gastroenterology
- 1985
It is concluded that metoclopramide is an important therapeutic adjunct in the management of diabetic gastroparesis and its therapeutic effects are mediated through its prokinetic properties as well as centrally mediated antiemetic actions.
Abdominal pain is a frequent symptom of gastroparesis.
- MedicineClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
- 2010
Prokinetics in Patients with Gastroparesis: A Systematic Analysis
- MedicineDigestion
- 1999
The data suggest that the motilin-agonist erythromycin is superior with regard to the acceleration of gastric emptying, while both eryhromycin and domperidone appear to be the most effective with regardto improvements in the symptom score.
Updates on treatment of irritable bowel syndrome.
- MedicineWorld journal of gastroenterology
- 2008
A physiologically-based overview of recently developed and frequently employed pharmaceutical agents used to treat IBS is provided, and some non-pharmaceutical options that may be beneficial in this disorder are discussed.
The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006.
- MedicineGastroenterology
- 2009
Gastroparesis is an uncommon condition in the community but is associated with a poor outcome and overall survival was significantly lower than the age- and sex-specific expected survival computed from the Minnesota white population.