Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes.

@article{Galan2006PathophysiologyAM,
  title={Pathophysiology and management of recurrent hypoglycaemia and hypoglycaemia unawareness in diabetes.},
  author={Bastiaan E. de Galan and B. J. J. W. Schouwenberg and Cees J.J. Tack and P. G. F. M. Smits},
  journal={The Netherlands journal of medicine},
  year={2006},
  volume={64 8},
  pages={269-79}
}
Iatrogenic hypoglycaemia is a well-known complication of insulin therapy in patients with diabetes mellitus and a limiting factor for glycaemic control. In a setting of endogenous insulin deficiency (type 1 and advanced type 2 diabetes), one episode of hypoglycaemia reduces both counterregulatory hormone responses to and subjective awareness of subsequent hypoglycaemia, thus impairing physiological defences against hypoglycaemia. This phenomenon may lead to a vicious cycle of recurrent… CONTINUE READING