Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.

@article{Kluge2012PathophysiologyAG,
  title={Pathophysiology and genetics of obesity and diabetes in the New Zealand obese mouse: a model of the human metabolic syndrome.},
  author={Reinhart Kluge and Stephan Scherneck and Annette Sch{\"u}rmann and H Joost},
  journal={Methods in molecular biology},
  year={2012},
  volume={933},
  pages={59-73}
}
The New Zealand Obese (NZO) mouse is one of the most thoroughly investigated polygenic models for the human metabolic syndrome and type 2 diabetes. It presents the main characteristics of the disease complex, including early-onset obesity, insulin resistance, dyslipidemia, and hypertension. As a consequence of this syndrome, a combination of lipotoxicity and glucotoxicity produces beta-cell failure and apoptosis resulting in hypoinsulinemia and diabetic hyperglycemia. With NZO as a breeding… CONTINUE READING