Pathophysiology and functional significance of apical membrane disruption during ischemia.

@article{Ashworth1999PathophysiologyAF,
  title={Pathophysiology and functional significance of apical membrane disruption during ischemia.},
  author={Sharon L Ashworth and Bruce A Molitoris},
  journal={Current opinion in nephrology and hypertension},
  year={1999},
  volume={8 4},
  pages={449-58}
}
The characteristic structure of polarized proximal tubule cells is drastically altered by the onset of ischemic acute renal failure. Distinctive apical brush border microvilli disruption occurs rapidly and in a duration-dependent fashion. Microvillar membranes internalize into the cytosol of the cell or are shed into the lumen as blebs. The microvillar actin core disassembles concurrent with or preceding these membrane changes. Actin and its associated binding proteins no longer interact to… CONTINUE READING