Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives.

@article{Kulkarni2003PathophysiologyAD,
  title={Pathophysiology and drug therapy of tardive dyskinesia: current concepts and future perspectives.},
  author={Shrinivas Krishnarao Kulkarni and P. S. Naidu},
  journal={Drugs of today},
  year={2003},
  volume={39 1},
  pages={19-49}
}
Nearly 1% of the world population suffers from schizophrenia, and neuroleptics are the major class of drugs used to treat this disorder. Neuroleptics are associated with wide variety of extrapyramidal side effects, such as akathesia, dystonia, neuroleptic malignant syndrome, Parkinson-ism and tardive dyskinesia. Despite the awareness that neuroleptics could cause extrapyramidal side effects, these drugs remain the most effective means of treating schizophrenia and Tourette's syndrome, as well… CONTINUE READING
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