Pathophysiology and Genetics of Bronchiectasis Unrelated to Cystic Fibrosis

@article{Nikolic2018PathophysiologyAG,
  title={Pathophysiology and Genetics of Bronchiectasis Unrelated to Cystic Fibrosis},
  author={Aleksandra Nikolic},
  journal={Lung},
  year={2018},
  volume={196},
  pages={383-392}
}
Bronchiectasis is characterized by deregulated inflammatory response and recurrent bacterial infection resulting in progressive lung damage and an irreversible dilatation of bronchi and bronchioles. Generally accepted model of the development of bronchiectasis is the “vicious cycle hypothesis” that proposes compromising of the mucociliary clearance by an initial event, which leads to the infection of the respiratory tract followed by further impairment of mucociliary function, bacterial… CONTINUE READING
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