Pathophysiology , distribution , sex differences and the role in inflammation and cancerogenesis
@inproceedings{Endokrynologii2007PathophysiologyD, title={Pathophysiology , distribution , sex differences and the role in inflammation and cancerogenesis}, author={Zakład Patofizjologii Katedry Patofizjologii i Endokrynologii}, year={2007} }
The role of adipose tissue is energy storage, but there is increasing evidence that adipocytes and adipokines are involved in metabolic and inflammatory processess. This paper reviews the pathophysiology of different adipose tissue depots. Interrelationships between sex hormones, adipose tissue and risk factors are also disscussed. Present study focuses on the effects of adipokines on immune system and on the mechanisms relating adiposity to cancer risk. (Pol J Endocrinol 2007; 58 (4): 330–342)
References
SHOWING 1-10 OF 60 REFERENCES
Role of adipose tissue as an inflammatory organ in human diseases.
- Biology, MedicineEndocrine reviews
- 2006
The present review discusses and summarizes the current knowledge on the inflammatory role of adipocytokines and special types of regional adipocytes such as retroorbital, synovial, visceral, subdermal, peritoneal, and bone marrow adipocytes in internal medicine diseases.
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
- BiologyNature Reviews Immunology
- 2006
Several adipocytokines have a central role in the regulation of insulin resistance, as well as many aspects of inflammation and immunity, and understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases.
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies.
- BiologyActa physiologica Scandinavica
- 2005
The main scope is to describe the biological functions of adipose tissue, and to focus on metabolic, hormonal, and signalling differences between fat depots.
A burning question: does an adipokine-induced activation of the immune system mediate the effect of overnutrition on type 2 diabetes?
- Medicine, BiologyDiabetes
- 2005
The exact chain of molecular events linking overnutrition, activation of the innate immune system, and impairment of insulin signaling in peripheral tissues remains incompletely understood.
Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity.
- BiologyHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- 2002
The present article summarizes some of the studies available on steroid hormone conversion through the specific expression of steroidogenic enzymes in adipose tissue (adipose tissue intracrinology)…
[The role of tumor necrosis factor (TNF-alpha) in control of metabolism].
- BiologyWiadomosci lekarskie
- 2005
The review of the current literature on the TNF-alpha role in metabolism is presented and its action on adipocytes includes increasing secretion of triglicerydes and inhibiting insulin action.
Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome.
- Medicine, BiologyEndocrine reviews
- 2000
Methods for assessment of several phenotypes of human obesity, with special reference to abdominal fat content, have been evaluated and the endocrine regulation of abdominal visceral fat in comparison with the adipose tissue localized in other areas is presented.
Role of Estrogens in Adipocyte Development and Function
- BiologyExperimental biology and medicine
- 2004
It is clear that estrogen plays a more important role in adipose tissue than originally realized and that it is a major regulator of adipose tissues in both sexes during development and adulthood.
Relationship between adipocyte size and adipokine expression and secretion.
- Biology, MedicineThe Journal of clinical endocrinology and metabolism
- 2007
There seems to be a differential expression of pro- and antiinflammatory factors with increasing adipocyte size resulting in a shift toward dominance of proinflammatory adipokines largely as a result of a dysregulation of hypertrophic, very large cells.
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
- Medicine, BiologyNature Reviews Cancer
- 2004
Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.