Pathophysiology, staging and therapy of severe sepsis in baboon models

@inproceedings{Taylor2012PathophysiologySA,
  title={Pathophysiology, staging and therapy of severe sepsis in baboon models},
  author={Fletcher B. Taylor and Gary T. Kinasewitz and Florea Lupu},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
We review our baboon models of Escherichia coli sepsis that mimic, respectively, the shock/disseminated intravascular coagulation (DIC) and organ failure variants of severe sepsis, and analyse the pathophysiologic processes that are unique to each. The multi-stage, multi-factorial characteristics of severe sepsis develop as a result of the initial insult, which - depending on its intensity - activates components of the intravascular compartment leading to overwhelming shock/DIC; or initiates a… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 55 references

Polyphosphate and omptins: novel bacterial procoagulant agents

Journal of cellular and molecular medicine • 2009
View 5 Excerpts
Highly Influenced

Role for the alternative complement pathway in ischemia/reperfusion injury.

The American journal of pathology • 2003
View 11 Excerpts
Highly Influenced

Innate immunity and coagulation.

Journal of thrombosis and haemostasis : JTH • 2011
View 1 Excerpt

CD14 inhibition efficiently attenuates early inflammatory and hemostatic responses in Escherichia coli sepsis in pigs.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2010
View 1 Excerpt

Leukocyte – endothelial interactions in inflammation

Journal of cellular and molecular medicine • 2009
View 1 Excerpt

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