Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases.

  title={Pathophysiological roles of interleukin-8/CXCL8 in pulmonary diseases.},
  author={Naofumi Mukaida},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={284 4},
  • N. Mukaida
  • Published 1 April 2003
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Fifteen years have passed since the first description of interleukin (IL)-8/CXCL8 as a potent neutrophil chemotactic factor. Accumulating evidence has demonstrated that various types of cells can produce a large amount of IL-8/CXCL8 in response to a wide variety of stimuli, including proinflammatory cytokines, microbes and their products, and environmental changes such as hypoxia, reperfusion, and hyperoxia. Numerous observations have established IL-8/CXCL8 as a key mediator in neutrophil… 

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