Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney.

@article{Rafiq2011PathophysiologicalRO,
  title={Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney.},
  author={Kazi Rafiq and Hirofumi Hitomi and Daisuke Nakano and Akira Nishiyama},
  journal={Journal of pharmacological sciences},
  year={2011},
  volume={115 1},
  pages={
          1-7
        }
}
Aldosterone, a steroid hormone, has traditionally been viewed as a key regulator of fluid and electrolyte homeostasis, as well as blood pressure, through the activation of mineralocorticoid receptor (MR). However, a number of studies performed in the last decade have revealed an important role of aldosterone/MR in the pathogenesis of renal injury. Aldosterone/MR-induced renal tissue injury is associated with increased renal inflammation and oxidative stress, fibrosis, mesangial cell… CONTINUE READING

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