Pathophysiological role of skin mast cells in wound healing after scald injury: study with mast cell-deficient W/W(V) mice.

@article{Shiota2010PathophysiologicalRO,
  title={Pathophysiological role of skin mast cells in wound healing after scald injury: study with mast cell-deficient W/W(V) mice.},
  author={Naotaka Shiota and Yoriko Nishikori and Eiichi Kakizoe and Keiko Shimoura and Tomomi Niibayashi and Chiko Shimbori and Tetsuya Tanaka and Hideki Okunishi},
  journal={International archives of allergy and immunology},
  year={2010},
  volume={151 1},
  pages={80-8}
}
BACKGROUND The major role of mast cells in wound healing process has not been identified. In this study, we used mast cell-deficient W/W(V) mice and their congenic control (+/+) mice to examine the role of mast cells in scald wound healing. METHODS The size of the scald wound, thickness of the dermis, collagen deposition, vascularization, number of mast cells and chymase activity were measured before and at 3, 7, 14 and 21 days after inducing scald injury. RESULTS Although the process of… CONTINUE READING

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