Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.

@article{Mnzel2015PathophysiologicalRO,
  title={Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications.},
  author={Thomas F. M{\"u}nzel and Tommaso Gori and John F. Keaney and Christoph Maack and Andreas Daiber},
  journal={European heart journal},
  year={2015},
  volume={36 38},
  pages={2555-64}
}
Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with an activation of the circulating and local renin-angiotensin-aldosterone system (RAAS), and with a subsequent inappropriately increased production of reactive oxygen species (ROS). While, at low concentrations, ROS modulate important physiological functions through changes in cellular signalling and gene expression, overproduction of ROS may adversely alter cardiac mechanics, leading to further worsening… CONTINUE READING