Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

@article{Clozel1993PathophysiologicalRO,
  title={Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist},
  author={Martine Clozel and Volker Breu and Kaspar Burri and J M Cassal and Walter Fischli and Gillian A Gray and Georges Hirth and Bernd-Michael L{\"o}ffier and Marcel Philipp M{\"u}ller and Werner Neidhart and Henri Ramuz},
  journal={Nature},
  year={1993},
  volume={365},
  pages={759-761}
}
SINCE its discovery1, endothelin-1 has attracted considerable scientific interest because of its extremely potent and long-lasting vasoconstrictor effect and its binding to G-protein-coupled receptors2. Plasma concentrations of endothelin-1 are low3 and its release by endothelial cells is polarized towards the basolateral side4,5, suggesting that it is a paracrine factor and not a hormone. Consequently, the effect of injected endothelin-1 may not reflect the effect of endogenous endothelin-1… CONTINUE READING

From This Paper

Topics from this paper.
98 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

Similar Papers

Loading similar papers…