Pathophysiological relevance of apical large-conductance Ca²+-activated potassium channels in pancreatic duct epithelial cells.

@article{Venglovecz2011PathophysiologicalRO,
  title={Pathophysiological relevance of apical large-conductance Ca²+-activated potassium channels in pancreatic duct epithelial cells.},
  author={Vikt{\'o}ria Venglovecz and P{\'e}ter Hegyi and Zolt{\'a}n Rakonczay and Laszlo Tiszlavicz and A Joseph Nardi and Morten Grunnet and Michael A. Gray},
  journal={Gut},
  year={2011},
  volume={60 3},
  pages={
          361-9
        }
}
BACKGROUND Acute pancreatitis is among the few inflammatory diseases for which no specific pharmacological treatment is available. It has previously been shown that bile acids alter pancreatic ductal secretion and these effects are probably involved in the pathogenesis of bile-induced pancreatitis. OBJECTIVE To understand the mechanism responsible for bile-induced hypersecretion and, in particular, to identify the molecular target for bile acids in native pancreatic duct epithelial cells… CONTINUE READING
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