Pathophysiological rationale and diagnostic targets for diastolic stress testing

@article{Erdei2015PathophysiologicalRA,
  title={Pathophysiological rationale and diagnostic targets for diastolic stress testing},
  author={Tam{\'a}s Erdei and Svend Aakhus and Paolo N Marino and Walter J. Paulus and Otto A. Smiseth and Alan G Fraser},
  journal={Heart},
  year={2015},
  volume={101},
  pages={1355 - 1360}
}
Cardiopulmonary functional reserve measured as peak oxygen uptake is predicted better at rest by measures of cardiac diastolic function than by systolic function. Normal adaptations in the trained heart include resting bradycardia, increased LV end-diastolic volume and augmented early diastolic suction on exercise. In normal populations early diastolic relaxation declines with age and end-diastolic stiffness increases, but in healthy older subjects who have exercised throughout their lives… 
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