Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.

@article{Wollnik1997PathophysiologicalMO,
  title={Pathophysiological mechanisms of dominant and recessive KVLQT1 K+ channel mutations found in inherited cardiac arrhythmias.},
  author={Bernd Wollnik and Bj{\"o}rn C. Schroeder and Christian Kubisch and Hans Dieter Esperer and Peter F. Wieacker and Thomas J Jentsch},
  journal={Human molecular genetics},
  year={1997},
  volume={6 11},
  pages={
          1943-9
        }
}
  • Bernd Wollnik, Björn C. Schroeder, +3 authors Thomas J Jentsch
  • Published in Human molecular genetics 1997
  • Biology, Medicine
  • The inherited long QT syndrome (LQTS), characterized by a prolonged QT interval in the electrocardiogram and cardiac arrhythmia, is caused by mutations in at least four different genes, three of which have been identified and encode cardiac ion channels. The most common form of LQTS is due to mutations in the potassium channel gene KVLQT1, but their effects on associated currents are still unknown. Different mutations in KVLQT1 cause the dominant Romano-Ward (RW) syndrome and the recessive… CONTINUE READING

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