Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity

  title={Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicity},
  author={L. Liaudet and B. Calderari and P. Pacher},
  journal={Heart Failure Reviews},
  • L. Liaudet, B. Calderari, P. Pacher
  • Published 2014
  • Medicine
  • Heart Failure Reviews
  • Overactivation of the sympatho-adrenergic system is an essential mechanism providing short-term adaptation to the stressful conditions of critical illnesses. In the same way, the administration of exogenous catecholamines is mandatory to support the failing circulation in acutely ill patients. In contrast to these short-term benefits, prolonged adrenergic stress is detrimental to the cardiovascular system by initiating a series of adverse effects triggering significant cardiotoxicity, whose… CONTINUE READING
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