Pathophysiological mechanisms of brain damage from status epilepticus.

@article{Wasterlain1993PathophysiologicalMO,
  title={Pathophysiological mechanisms of brain damage from status epilepticus.},
  author={Claude Guy Wasterlain and Denson G. Fujikawa and Laroy Penix and Ramkumar Sankar},
  journal={Epilepsia},
  year={1993},
  volume={34 Suppl 1},
  pages={
          S37-53
        }
}
Human status epilepticus (SE) is consistently associated with cognitive problems, and with widespread neuronal necrosis in hippocampus and other brain regions. In animal models, convulsive SE causes extensive neuronal necrosis. Nonconvulsive SE in adult animals also leads to widespread neuronal necrosis in vulnerable regions, although lesions develop more slowly than they would in the presence of convulsions or anoxia. In very young rats, nonconvulsive normoxic SE spares hippocampal pyramidal… CONTINUE READING
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