Pathophysiological factors affecting CAR gene expression.

  title={Pathophysiological factors affecting CAR gene expression.},
  author={Jean Marc Pascussi and Zdenek Dvorak and Sabine Gerbal-chaloin and Eric Ass{\'e}nat and Patrick Maurel and Marie Jos{\'e} Vilarem},
  journal={Drug metabolism reviews},
  volume={35 4},
The body defends itself against potentially harmful compounds, such as drugs and toxic endogenous compounds and their metabolites, by inducing the expression of enzymes and transporters involved in their metabolism and elimination. The orphan nuclear receptor CAR (NR1I3 controls phase I (CYP2B, CYP2C, CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance. Constitutive androstane receptor (CAR) is activated by xenobiotics, such as… CONTINUE READING