Pathophysiological effects of aldosterone in cardiovascular tissues.

  title={Pathophysiological effects of aldosterone in cardiovascular tissues.},
  author={Ricardo Dantas Rocha and Charles T. Stier},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={12 7},
The advent of antihypertensive therapy has resulted in a significant decrease in cardiovascular morbidity and mortality. Nevertheless, the incidence of heart failure, stroke and end-stage renal failure continues to increase. This trend suggests that a mechanism, independent of hypertension, is responsible for end-organ damage. Genetic and experimental models of hypertension have demonstrated that excess aldosterone induces severe injury in the heart, brain and kidneys, and that pharmacological… CONTINUE READING
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