Corpus ID: 198961595

Pathophysiological correlations between obstructive sleep apnea syndrome and atrial fibrillation

@inproceedings{Alexandrina2019PathophysiologicalCB,
  title={Pathophysiological correlations between obstructive sleep apnea syndrome and atrial fibrillation},
  author={Liliana Alexandrina and Grigoriu and - ȘtefanDumitrache and Rujinski and Radu and Gabriel Vătășescu and Miron Alexandru and Bogdan},
  year={2019}
}
Corresponding author: Liliana Alexandrina Grigoriu, MD E-mail alexalili@yahoo.com Atât sindromul de apnee în somn de tip obstructiv (SASO), cât și fibrilația atrială (FA) reprezintă afecțiuni frecvent întâlnite în rândul populației, cu un impact deosebit asupra calității vieții și cu importante consecințe la nivel de morbiditate și mortalitate. S-a observat că aceste două boli se asociază frecvent, se pot potența negativ, iar cunoașterea mecanismelor fiziopatologice care interferează în aceste… Expand

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TLDR
OSA is associated with significant atrial remodeling characterized by atrial enlargement, reduction in voltage, site-specific and widespread conduction abnormalities, and longer sinus node recovery, which may in part explain the association between OSA and AF. Expand
Obstructive Sleep Apnea as a Risk Factor for Atrial Fibrillation: A Meta-Analysis
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OSA/SDB is strongly associated with AFib confirming the notion that OSA/ SDB populations are high risk for development of AF, a growing health burden with serious consequences. Expand
Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities
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Large-scale collaborative studies of carefully defined patient populations with obstructive sleep apnoea syndrome, adequately controlled for potential confounders, are needed and research priorities to identify the underlying mechanisms involved are proposed, with a view to identifying novel therapeutic strategies. Expand
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TLDR
Obesity and acute obstructive apnea interacted to promote AF in this model, and forced inspiration-induced acute LA distension related to diastolic dysfunction may be an important component of the arrhythmogenic substrate for AF during OSA episodes in obese patients. Expand
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TLDR
Treatment of OSA, particularly with continuous positive airway pressure, seems to substantially reduce the frequency of Atrial fibrillation, and if true, this approach would provide a safe and noninvasive therapy for some patients with AF. Expand
Treatment of obstructive sleep apnea reduces the risk of atrial fibrillation recurrence after catheter ablation.
TLDR
CPAP is an important therapy in OSA patients undergoing PVI that improves arrhythmia free survival and PVI offers limited value to OSA Patients not treated with CPAP. Expand
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TLDR
It is found that a strong association exists between OSA HS and AF, such that AF is strikingly more prevalent in patients with OSAHS than in control group. Expand
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TLDR
Chronically repeated OSA episodes cause AF-promoting cardiac remodeling, with conduction abnormalities related to connexin dysregulation and fibrosis playing a prominent role and this novel animal model provides mechanistic insights into an important clinical problem and may be useful for further exploration of underlying mechanisms and therapeutic approaches. Expand
Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation
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Therapy with continuous positive airway pressure is associated with lower blood pressure, atrial size, and ventricular mass, and a lower risk of AF recurrence after pulmonary venous isolation (PVI). Expand
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TLDR
Evidence supports the fact that, as individuals grow older, there is a decrease in muscle tonus, with a consequent reduction in the dimensions of the upper airway lumen, and decreased ventilatory drive has been detected in patients with obstructive sleep apnea syndrome and hypercapnia. Expand
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