Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway.

@article{Kawamura1994PathophysiologicalCO,
  title={Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway.},
  author={Mitsunobu Kawamura and Jay W. Heinecke and Alan Chait},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={94 2},
  pages={771-8}
}
Oxidized lipoproteins may be important in the pathogenesis of atherosclerosis. Because diabetic subjects are particularly prone to vascular disease, and glucose autoxidation and protein glycation generate reactive oxygen species, we explored the role of glucose in lipoprotein oxidation. Glucose enhanced low density lipoprotein (LDL) oxidation at concentrations seen in the diabetic state. Conjugated dienes, thiobarbituric acid reactive substances, electrophoretic mobility, and degradation by… CONTINUE READING
76 Citations
30 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 76 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

The influence of oxidatively modified lipoproteins on expression of platelet - derived growth factor by human monocyte - derived macrophages

  • G. M. Chisolm
  • J . Biol . Chem .
  • 1991

Similar Papers

Loading similar papers…