Pathophysiological basis of migraine prophylaxis.

  title={Pathophysiological basis of migraine prophylaxis.},
  author={Francesca Galletti and Letizia Maria Cupini and I Corbelli and Paolo Calabresi and Paola Sarchielli},
  journal={Progress in neurobiology},
  volume={89 2},
Several cellular and molecular mechanisms have been implicated in migraine pathophysiology including abnormal neuronal excitability and vascular events. Drugs from different pharmacological classes are used for migraine prophylaxis. These agents may normalize neuronal excitability by modulating distinct ionic channels and various neurotransmitter systems. They can also block cortical spreading depression, prevent peripheral and/or central pain sensitization, and normalize brainstem function… CONTINUE READING