Pathophysiological and genetic characterization of the major diabetes locus in GK rats.

@article{Galli1999PathophysiologicalAG,
  title={Pathophysiological and genetic characterization of the major diabetes locus in GK rats.},
  author={Joakim Galli and Hossein Fakhrai-Rad and Ashraf Ahmad Kamel and Claude Marcus and Svante Norgren and Holger Luthman},
  journal={Diabetes},
  year={1999},
  volume={48 12},
  pages={2463-70}
}
Genetic studies of the type 2 diabetes-like GK rat have revealed several susceptibility loci for the compound diabetes phenotype. Congenic strains were established for Niddm1, the major quantitative trait locus (QTL) for postprandial glucose levels, by transfer of GK alleles onto the genome of the normoglycemic F344 rat. Despite the polygenic nature of diabetes in GK, the locus-specific diabetes phenotype was retained in the congenic strain Niddmla, containing a GK-derived genomic fragment of… CONTINUE READING

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