Pathophysiological and clinical aspects of combat anticholinesterase poisoning.

@article{Weinbroum2004PathophysiologicalAC,
  title={Pathophysiological and clinical aspects of combat anticholinesterase poisoning.},
  author={Avi A Weinbroum},
  journal={British medical bulletin},
  year={2004},
  volume={72},
  pages={
          119-33
        }
}
Nerve agents are organophosphate compounds similar to those used as pesticides but with much higher toxicity. They all block the activity of the enzyme acetylcholine esterase. Victims are intoxicated by absorption of the toxin via exposed skin or, more commonly, via inhalation of the poisonous gas. The resultant clinical picture is of hyperstimulation of both the nicotinic and muscarinic cholinergic system, which, if not promptly treated, leads to severe muscle paralysis, cardiac brady-asystole… 
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