Corpus ID: 53699563

Pathophysiological Mechanisms of Mercury’s Effect on Thyroid Gland

  title={Pathophysiological Mechanisms of Mercury’s Effect on Thyroid Gland},
  author={Rija Zehra and Syed S. Fatmi and D. Carpenter},
  • Rija Zehra, Syed S. Fatmi, D. Carpenter
  • Published 2018
  • Medicine
  • With acute exposure, mercury has high affinity for thyroid tissue causing atrophic changes in thyroid gland. Inhibition of coupling, antagonism of deiodinases and induction of autoimmune reactions are the three fundamental pathophysiologic mechanisms that have been documented as it relates to mercury’s effect on thyroid. Mercury inhibits the coupling process through inhibition of iodide incorporation into iodothyronine fraction. Thyroid hormone has an inverse relationship with body mercury… CONTINUE READING


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