Pathophysiologic role of histamine: evidence clarified by histidine decarboxylase gene knockout mice.

@article{Ohtsu2012PathophysiologicRO,
  title={Pathophysiologic role of histamine: evidence clarified by histidine decarboxylase gene knockout mice.},
  author={Hiroshi Ohtsu},
  journal={International archives of allergy and immunology},
  year={2012},
  volume={158 Suppl 1},
  pages={2-6}
}
The role of histamine in various murine disease models has been clarified using histidine decarboxylase gene knockout mice. The mice were generated using conventional gene-targeting methods. Studies, including ours, using knockout mice have shown that the activity of histamine is not limited to allergic, peptic and neurologic functions as in the old… CONTINUE READING