Pathophysiologic mechanisms in acquired aplastic anemia.

  title={Pathophysiologic mechanisms in acquired aplastic anemia.},
  author={Neal S. Young},
  journal={Hematology. American Society of Hematology. Education Program},
  • Neal S. Young
  • Published 2006 in
    Hematology. American Society of Hematology…
Aplastic anemia, an unusual hematologic disease, is the paradigm of the human bone marrow failure syndromes. Absence of hematopoietic cells has been recognized from the characteristic morphology for a century; an immune pathophysiology has been inferred from improvement in blood counts with immunosuppressive therapy in the majority of patients. Molecular mechanisms underlying both T cell effector cells and the target marrow stem and progenitor cells are now being identified. Activated type 1… CONTINUE READING
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Genetic variation In telomeric repeat binding factor 1 but not telomeric repeat binding factor 2 are associated with aplastic anemia

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Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients

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