Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies.

@article{Horsman2006PathophysiologicEO,
  title={Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies.},
  author={Michael Robert Horsman and Dietmar W. Siemann},
  journal={Cancer research},
  year={2006},
  volume={66 24},
  pages={11520-39}
}
A functional vascular supply is critical for the continued growth and development of solid tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led to the concept of targeting the vasculature of the tumor as a form of cancer therapy. Two major types of vascular-targeting agent (VTA) have now emerged: those that prevent the angiogenic development of the neovasculature of the tumor and those that specifically damage the already established tumor vascular… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 111 extracted citations

Bioassay-guided isolation of an alkaloid with antiangiogenic and antitumor activities from the extract of Fissistigma cavaleriei root.

Phytomedicine : international journal of phytotherapy and phytopharmacology • 2012
View 3 Excerpts
Highly Influenced

Interventions that induce modifications in the tumor microenvironment.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique • 2011
View 3 Excerpts
Highly Influenced

Experimental Anticancer Therapy with Vascular-disruptive Peptide and Liposome-entrapped Chemotherapeutic Agent

Archivum Immunologiae et Therapiae Experimentalis • 2010
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 262 references

Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas.

International journal of radiation oncology, biology, physics • 2003
View 4 Excerpts
Highly Influenced

Anti-vascular approaches to solid tumour therapy: evaluation of Pathophysiologic Effects of VTAs www.aacrjournals.org

SA Hill, LE Sampson, DJ. Chaplin
Cancer Res • 2006
View 6 Excerpts
Highly Influenced

Vasculature-disrupting strategies combined with bacterial spores targeting hypoxic regions of solid tumors. In: Siemann DW, editor. Vascular-targeted therapies in oncology

Ahn G-O, JM Brown
2006
View 20 Excerpts
Highly Influenced

Disrupting tumour blood vessels

Nature Reviews Cancer • 2005
View 6 Excerpts
Highly Influenced

Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005
View 14 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…