Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation.

@article{Jubran1997PathophysiologicBO,
  title={Pathophysiologic basis of acute respiratory distress in patients who fail a trial of weaning from mechanical ventilation.},
  author={Amal Jubran and Martin J. Tobin},
  journal={American journal of respiratory and critical care medicine},
  year={1997},
  volume={155 3},
  pages={
          906-15
        }
}
To determine the mechanisms of acute respiratory distress and failure in patients with chronic obstructive pulmonary disease (COPD), we studied 17 ventilator-supported patients who failed a trial of spontaneous breathing and 14 patients who tolerated such a trial and were successfully extubated. Immediately before the weaning trials, maximal inspiratory pressure was not statistically different between the two groups (p = 0.48). On discontinuation of the ventilator, the failure group immediately… CONTINUE READING

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