Pathomechanisms of type 2 diabetes genes.

  title={Pathomechanisms of type 2 diabetes genes.},
  author={Harald Staiger and Fausto Machicao and Andreas Fritsche and Hans-Ulrich H{\"a}ring},
  journal={Endocrine reviews},
  volume={30 6},
Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance and beta-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and represents a polygenic disease. During the last decade, considerable progress was made in the identification of type 2 diabetes risk genes. This was crucially influenced by the development of affordable high-density single nucleotide polymorphism (SNP) arrays that prompted several successful genome-wide… CONTINUE READING


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