Pathomechanism of Ligamentum Flavum Hypertrophy: A Multidisciplinary Investigation Based on Clinical, Biomechanical, Histologic, and Biologic Assessments

@article{Sairyo2005PathomechanismOL,
  title={Pathomechanism of Ligamentum Flavum Hypertrophy: A Multidisciplinary Investigation Based on Clinical, Biomechanical, Histologic, and Biologic Assessments},
  author={Koichi Sairyo and Ashok Biyani and Vijay K. Goel and Douglas W. Leaman and Robert E. Booth and Jean Thomas and Daniel J Gehling and L. Vishnubhotla and Rebecca Long and Nabil A Ebraheim},
  journal={Spine},
  year={2005},
  volume={30},
  pages={2649-2656}
}
Study Design. A multidisciplinary study involving clinical, histologic, biomechanical, biologic, and immunohistologic approaches. Objective. To clarify the pathomechanism of hypertrophy of the ligamentum flavum. Summary of Background Data. The most common spinal disorder in elderly patients is lumbar spinal canal stenosis, causing low back and leg pain, and paresis. Canal narrowing, in part, results from hypertrophy of the ligamentum flavum. Although histologic and biologic literature on this… 

Pathomechanism of Loss of Elasticity and Hypertrophy of Lumbar Ligamentum Flavum in Elderly Patients With Lumbar Spinal Canal Stenosis

Investigation of the pathomechanism of loss of elasticity and hypertrophy of the lumbar ligamentum flavum (LF) in the elderly population found decreased elasticity is due to the Loss of elastic fibers and a concomitant increase of collagenous fibers in the dorsal aspect and this could be due to a thickening of the normal elastic layer as well as of the abnormal collagenous layer.

Chondrogenic and Fibrotic Process in the Ligamentum Flavum of Patients With Lumbar Spinal Canal Stenosis

Synthesis of the collagenous fibers and degradation of the elastic and collagenous fiber are both accelerated in the ligamentum flavum of patient with LSCS, which may be the reason for hypertrophy of the tissue.

Lumbar Ligamentum Flavum Hypertrophy Is Due to Accumulation of Inflammation-Related Scar Tissue

It is proposed that the hypertrophy of the ligamentum flavum is caused by accumulation of inflammation-related scar tissue, and it might be possible to prevent the hyperTrophy of ligamentu flavum with antiinflammatory drugs.

The Role of the Ligamentum Flavum Area as a Morphological Parameter of Lumbar Central Spinal Stenosis.

Although the LFT and LFA were both significantly associated with LCSS, the LFA was a more sensitive measurement parameter, and to evaluate LCSS patients, the treating doctor should more carefully analyze the L FA than LFT.

Clinical outcome of lumbar spinal stenosis based on new classification according to hypertrophied ligamentum flavum.

Analysis of the Relationship between Hypertrophy of the Ligamentum Flavum and Lumbar Segmental Motion with Aging Process

Age-related increases in disc degeneration, combined with continuous lumbar segmental flexion-extension motion, leads to the development of LF hypertrophy.

LIGAMENTUM FLAVUM HYPERTROPHY IN ELDERLY PATIENTS WITH LOW BACK PAIN: A MRI STUDY

In elderly patients, LF hypertrophy was correlated with age, LSCS, spinal level, and disc degeneration, and not with disc herniation and gender.

Factors Associated With the Thickness of the Ligamentum Flavum: Is Ligamentum Flavum Thickening Due to Hypertrophy or Buckling?

Thickening of the LF is correlated with disc degeneration, aging, BMI, LSS, spinal level, and disc herniation and is concluded that thickening ofThe LF is due to buckling of the LF into the spinal canal secondary to disc degenerations more than to LF hypertrophy.

Morphological Changes in the Ligamentum Flavum in Degenerative Lumbar Canal Stenosis: A Prospective, Comparative Study

Characteristic morphological changes may be noted on histopathological and electron microscopic examination that mark the degenerative changes in the LF that contribute to the occurrence and pathogenesis of degenerative LCS.
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