Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes.

@article{Freitas1999PathologyOT,
  title={Pathology of the spleen in hepatosplenic schistosomiasis. Morphometric evaluation and extracellular matrix changes.},
  author={C. R. Freitas and A. Barbosa and A. L. Fernandes and Z. Andrade},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={1999},
  volume={94 6},
  pages={
          815-22
        }
}
Histological, ultrastructural, morphometric and immunohistochemical data obtained from the study of spleens removed by splenectomy from 34 patients with advanced hepatosplenic schistosomiasis revealed that the main alterations were congestive dilatation of the venous sinuses and diffuse thickening of the splenic cords. Splenic cord thickening was due to an increase of its matrix components, especially type IV collagen and laminin, with the conspicuous absence of interstitial collagens, either… Expand
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