Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004.

@article{Nakamura2008PathologyOS,
  title={Pathology of specific-pathogen-free chickens inoculated with H5N1 avian influenza viruses isolated in Japan in 2004.},
  author={Kikuyasu Nakamura and Tadao Imada and Kunitoshi Imai and Yu Yamamoto and Nobuhiko Tanimura and Manabu Yamada and Masaji Mase and Kenji Tsukamoto and Shigeo Yamaguchi},
  journal={Avian diseases},
  year={2008},
  volume={52 1},
  pages={
          8-13
        }
}
Specific-pathogen-free chickens inoculated with H5N1 highly pathogenic avian influenza (HPAI) viruses isolated in Japan in 2004 were investigated pathologically. The chickens inoculated intravenously with the viruses died within 26 hr after inoculation. Macroscopically, minimal necrosis of the tip of the comb, and hemorrhages of the palpebral conjunctiva, liver, cerebellum, and muscles were rarely observed. Histologically, dead chickens had minimal focal necrosis of hepatocytes with fibrinous… CONTINUE READING
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