Pathology of sarcoidosis.

  title={Pathology of sarcoidosis.},
  author={Yale Rosen},
  journal={Seminars in respiratory and critical care medicine},
  volume={28 1},
  • Y. Rosen
  • Published 1 February 2007
  • Medicine
  • Seminars in respiratory and critical care medicine
The role of pathology in the diagnosis of sarcoidosis is identification of granulomas in tissue specimens and performance of studies to exclude known causes of granulomatous inflammation. The granulomas of sarcoidosis are nonspecific lesions that, by themselves and in the absence of an identifiable etiologic agent, are not diagnostic of sarcoidosis or any other specific disease. Among the diseases to be excluded are mycobacterial, fungal, and parasitic infections, chronic beryllium disease and… 

The Diagnosis, Differential Diagnosis, and Treatment of Sarcoidosis.

  • A. Prasse
  • Medicine
    Deutsches Arzteblatt international
  • 2016
The treatment of patients with sarcoidosis, particularly those with complicated disease courses, requires close collaboration of the primary care physician with a specialized interdisciplinary center.

The diagnosis of sarcoidosis.

  • M. Judson
  • Medicine
    Current opinion in pulmonary medicine
  • 2019
The diagnosis of sarcoidosis usually involves weighing the clinical evidence for and against the diagnosis, coupled in most cases with histologic evidence of granulomatous inflammation.

Sarcoidosis and the Nervous System.

This article provides an overview and update on the neurologic manifestations of sarcoidosis and indicates that infliximab appears to be efficacious when other treatments are inadequate and steroid-sparing agents are used for prolonged therapy to minimize steroid toxicity.

Necrotizing sarcoid granulomatosis: a case report and review of progresses in this disease

A young male who visited the emergency room with progressive dyspnea and left sided chest pain was diagnosed with Necrotizing Sarcoid Granulomatosis (NSG) and treated with corticosteroids.

Pulmonary sarcoidosis: An important differential diagnosis in transbronchial lung biopsies

Transbronchial lungBiopsies have become an important tool in the diagnosis of sarcoidosis in present time and should be considered as a differential diagnosis when dealing with granulomatous lesions in lung biopsies, says this retrospective study.

Sarcoidosis and tuberculosis: the same disease with different manifestations or similar manifestations of different disorders

The balance of evidence favors mycobacteria or their products as a trigger for inciting immune responses leading to sarcoidosis in a proportion of patients, which is likely to be higher in countries with high tuberculosis burden, and highlights the limitations of molecular or serological studies to discriminate between the two conditions.

Host-microbe interactions in the pathogenesis and clinical course of sarcoidosis

The scientific evidence on the interaction of microbes with immune cells that may be implicated in the immunopathogenesis of sarcoidosis is discussed, and recent studies exploring potential implications of human microbiota in the pathogenesis and the clinical course are highlighted.

Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma

The present review focuses on the residual risk of the coexistence of metastases within radiological suspicious lesions in patients with a history of solid tumors and sarcoidosis, as well as immunological findings, in order to explain the potential associations.

New opportunities of computer tomography in diagnostics of pleural lesion in sarcoidosis

It is established that the main morphological elements are not lymphadenopathy without pulmonary pleural changes, but a combination of enlarged bronchopulmonary lymph nodes, granulomatous changes in the lung parenchyma and pleura, which is confirmed by the results of X-ray morphological studies with the maximum use of post-processing.



The spectrum of biopsy sites for the diagnosis of sarcoidosis.

As shown by ACCESS, sarcoidosis offers a wide spectrum of diagnostic biopsy sites and the choice for biopsy is influenced by the presenting clinical constellation of organ involvement and the ease and safety of the biopsy procedure.

Solitary necrotizing granulomas of the lung: differentiating features and etiology.

A prominent overlapping spectrum of histologic features was found between infectious granulomas and Wegener's granulomatosis, suggesting that the latter may represent an abnormal immune response to an infectious agent that is no longer identifiable within the tissue.

Solitary necrotizing granulomas of the lung: Differentiating features and etiology

A prominent overlapping spectrum of histologic features was found between infectious granulomas and Wegener's granulomatosis, suggesting that the latter may represent an abnormal immune response to an infectious agent that is no longer identifiable within the tissue.

Histologic, microbiologic, and clinical correlates of the diagnosis of sarcoidosis by transbronchial biopsy.

Clinopathologic assessment of transbronchial biopsy specimens is useful in predicting the final diagnosis of sarcoidosis but does not obviate the need for microbiologic cultures, which were positive in 10.9% of patients in this study.

Necrotizing sarcoid granulomatosis--is it different from nodular sarcoidosis?

Nodular aggregates of granulomas in NSG were similar to those seen in nodular sarcoidosis, and the only unique feature of NSG is infarct-like necrosis, induced by the vasculitis, leading ultimately to vascular obstruction.

Incidence and nature of primary granulomatous inflammation in surgically removed material

Overall, the majority of the granulomas were due to five causes: sarcoidosis, mycobacterial infection, particulate inclusions, fungal infection, and rheumatoid arthritis.

Sarcoidosis and systemic vasculitis.

Sarcoidosis may be complicated by systemic vasculitis that can affect small- to large-caliber vessels and African American and Asian patients are disproportionately represented among cases with large vessel involvement.

Necrotizing sarcoid granulomatosis with suppurative features.

A patient initially presenting with the typical clinical and pathologic features of necrotizing sarcoid granulomatosis who, on subsequent recurrence, demonstrated a suppurative character to the necrosis has not been reported previously, and its recognition will allow more cases to be diagnosed correctly.

Spectrum of pleural involvement in sarcoidosis.

Clinical involvement of the pleura in sarsoidosis remains an unusual entity, but it may be that histologic involvement ofThe pleura is more common than generally appreciated.

Pulmonary vascular involvement in sarcoidosis: granulomatous angiitis and microangiopathy in transbronchial lung biopsies

The present study revealed coexistence of granulomatous angiitis and microangiopathy in the lung with sarcoidosis and suggests that both may participate in the development of pulmonary sarcoidsosis.