Pathology of pulmonary thromboembolism.

  title={Pathology of pulmonary thromboembolism.},
  author={Cornelis Adriaan Wagenvoort},
  volume={107 1 Suppl},
The incidence of pulmonary thromboembolism is hard to assess by the pathologist as a result of seasonal variation of embolism and disappearance of emboli by thrombolysis. However, the great differences in estimates of the incidence in routine hospital autopsies is mainly related to variation in scrutiny of the investigation and in size of area searched microscopically. Obstruction of major pulmonary arteries almost always results from thromboembolism which is most often found in its acute stage… 

An unusual case of SADDLE Pulmonary Thrombo Embolism

A large saddle thromboembolus with pulmonary infarction in a 50 year old smoker presented with DVT of his right lower limb venous system was presented and he was successfully managed with anticoagulants without the need for surgical intervention.

The Pathobiology of Chronic Thromboembolic Pulmonary Hypertension.

Current research focuses on the question as to whether a genetic predisposition leads to misguided vascular healing after pulmonary thromboembolism in susceptible individuals.

Pulmonary Embolic Disorders

The aim of this review is to aid the pathologist in using proper terminology, diagnosing various types of embolic disorders, and recognizing potential mimics.

Is pulmonary embolism a common cause of chronic pulmonary hypertension? Limitations of the embolic hypothesis.

It is hypothesized that in situ thrombosis and pulmonary arteriopathy are common causes of vascular occlusion which is usually diagnosed as "chronic thromboembolic pulmonary hypertension" and that venous throm boembolism is unlikely to be a common cause of chronic pulmonary hypertension.

The Medicolegal Evaluation of Fatal Pulmonary Thromboembolism

The detection of a saddle embolism at autopsy does not signify the end of the investigation because the underlying risk factors still may need to be determined, and the gross, microscopical, and genetic findings can distinguish various thrombotic risk factors and etiologies.

Pulmonary infarction in acute pulmonary embolism.

Acute Pulmonary Embolism

The treatment involves immediate anticoagulation, usually with heparin, or more recently with NOACs, and in experienced centres—surgical embolectomy or percutaneous catheter-directed treatment with low dose thrombolysis assisted with ultrasound.

Pathophysiology of Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

The prevalence and incidence of chronic thromboembolic pulmonary hypertension (CTEPH) following acute pulmonary embolism (PE) is difficult to ascertain. However, recent follow-up studies in patients

From the archives of the AFIP: pulmonary vasculature: hypertension and infarction.

Pulmonary hypertension is the hemodynamic consequence of vascular changes within the precapillary (arterial) or postcapillary (venous) pulmonary circulation, and may develop secondary to focal venous constriction or to compromised pulmonary venous drainage due to left atrial neoplasia, mitral stenosis, or left ventricular failure.

Acquired abnormalities of the pulmonary arteries.

Contrast-enhanced MDCT has emerged as the reference standard for the detection of PE owing to improved visualization of the pulmonary arteries, fast acquisition time, and widespread availability.



Pulmonary emboli. A factor in the etiology and pathogenesis of pulmonary emphysema.

Pulmonary embolism occurs in from 1.5 to 25 per cent of routine necropsies and it is often found in the absence of a history of venous thrombosis and may be the cause of localized, lobar, or unilateral pulmonary emphysema.

Thrombotic lesions in primary plexogenic arteriopathy. Similar pathogenesis or complication?

In 78 patients with primary plexogenic arteriopathy (PPA), numbers of organized and recanalized thrombi were established in histologic slides of lung tissue and expressed per square centimeter of

Pulmonary vascular lesions occurring in patients with chronic major vessel thromboembolic pulmonary hypertension.

Primary pulmonary hypertension cannot be differentiated from potentially correctable CTEPH on the basis of histopathologic findings in small pulmonary arteries, and development of these hypertensive changes may explain the deterioration which these patients experience preoperatively over time.

Venous Thrombosis and Pulmonary Embolism

Techniques of venous thrombosis clinical features phlebography pathology of pulmonary embolism radiology and lung scanning in diagnosis prevention medical treatment and chronic venous insufficiency are presented.

Longterm follow-up of patients with pulmonary thromboembolism. Late prognosis and evolution of hemodynamic and respiratory data.

Repeated hemodynamic investigation proved to be of minor prognostic value and no correlation was found between the longterm changes of PPA and age, duration of disease, interval between catheterizations, PaO2, or cardiac output.

Primary pulmonary hypertension

  • S. Rich
  • Medicine, Biology
    Progress in cardiovascular diseases
  • 1988
Evidence for endothelial cell dysfunction in pulmonary hypertensive states points to injury of the pulmonary vascular endothelium as the initiating event in the development of pulmonary hypertension, and lung transplantation appears effective for patients refractory to medical therapy.

Focal pulmonary embolism presenting as diffuse pulmonary edema.

This case illustrates that pulmonary emboli should always be considered in the differential diagnosis of pulmonary edema, and involves the release of humoral factors leading to extravasation of fluid across pulmonary capillary membranes.

Progressive pulmonary vascular obstruction and cor pulmonale due to repeated embolism from axillary vein thrombosis.

Abstract A case of posttraumatic axillary vein thrombosis in an otherwise healthy young man gave rise to rapidly progressive obstructive pulmonary hypertension, a result of recurrent thromboembolis...

Biopsy Pathology of the Pulmonary Vasculature

The open lung biopsy processing of biopsy specimens the normal lung vessels physiology and pathophysiology of the pulmonary circulation plexogenic arteriopathy evaluation of corrective operability of congenital heart disease thrombotic arteriopathies and neoplastic disorders unexplained pulmonary hypertension.