Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis).

@article{Kuiken2003PathologyOH,
  title={Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis).},
  author={Thijs Kuiken and G F Rimmelzwaan and Geert van Amerongen and Albert D M E Osterhaus},
  journal={Veterinary pathology},
  year={2003},
  volume={40 3},
  pages={304-10}
}
Infection with influenza A (H5N1) virus, which has not been associated with respiratory disease in humans previously, caused clinical signs of acute respiratory distress syndrome and multiple-organ dysfunction syndrome with high mortality in humans in Hong Kong in 1997. To study the pathogenesis of this disease, we infected four cynomolgus monkeys (Macaca fascicularis) with 2.5 x 104 median tissue culture infectious dose (TCID50) of influenza virus A/Hong Kong/156/97 (H5N1) and euthanatized… CONTINUE READING