Pathology of dietary carbonyl iron overload in rats.

  title={Pathology of dietary carbonyl iron overload in rats.},
  author={Chang-Hwan Park and Bruce R. Bacon and Gary M. Brittenham and Anthony S. Tavill},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  volume={57 5},
Serial light microscopic and ultrastructural studies were performed in rats with experimental iron overload produced by dietary supplementation with carbonyl (elemental) iron over a 12-month period. Hepatic iron increased rapidly to concentrations approximately 40 to 90 times those of control rats by 3 months. Within the liver, iron deposition was initially confined to periportal (zone 1) hepatocytes but subsequently extended to midzonal (zone 2) and centrilobular (zone 3) hepatocytes… CONTINUE READING