Pathology of Neonatal Calf Diarrhea Induced by a Coronavirus-Like Agent

  title={Pathology of Neonatal Calf Diarrhea Induced by a Coronavirus-Like Agent},
  author={Charles A. Mebus and Ernest L. Stair and Marvin B. Rhodes and M. J. Twiehaus},
  journal={Veterinary Pathology},
  pages={45 - 64}
Lesions induced by a bovine coronavirus-like agent were studied in gnotobiotic and colostrum-fed calves using gross, histologic and electron microscopic procedures. Lesions in gnotobiotic calves were present in the colon, mesenteric lymph nodes and in all segments of the small intestine. Calves killed 4 h after the onset of diarrhea had immunofluorescent epithelial cells on the villi of the small intestine and surface of the colon. Calves killed at 44 h had shortened intestinal villi and… Expand
The pathogenesis of an enteric infection in pigs, experimentally induced by the coronavirus-like agent, CV 777
The pathogenesis of this infection was similar to that of transmissible gastroenteritis (TGE), a known coronaviral infection of pigs, but where were some differences. Expand
Pathology of Infectious Diarrhea of Infant Rats (IDIR) Induced by an Antigenically Distinct Rotavirus
These studies show that two important diagnostic features of group B rotaviral infections of rats, epithelial syncytia and viral antigen as determined by immunofluorescence, are present only on the first day of disease. Expand
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Summary Seven conventional newborn calves were inoculated orally with the coronavirus strain LY‐138, originally recovered from naturally‐infected diarrheic calves. All calves developed diarrheaExpand
Studies with an unclassified virus isolated from diarrheic calves
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Examination of the small intestine of Neonatal calves for pathological changes and the presence and distribution of infectious agents complements bacteriological, virological and immunological techniques in the diagnosis of neonatal enteritis. Expand
Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves
The results show that the WD-BCoV has dual tropism and induces pathological changes in both the digestive and respiratory tracts of calves, the first detailed report of dual enteric and respiratory tropisms of WD- BCoV in calves. Expand
Lesions of Gnotobiotic Calves Experimentally Infected with a Calicivirus-like (Newbury) Agent
Small intestinal damage, first detected at 12 hours after infection but almost repaired by ten days, was restricted to the anterior half of the small intestine, and villi lengthened—possibly due to increased mitosis of crypt cells stimulated by enteroglucagon release. Expand
The Mucosal Lesion in Viral Enteritis
It is concluded that extensive, almost simultaneous direct viral invasion of villus enterocytes can occur along the entire length of the small intestine after a single exposure to virus, and thus can cause shedding of mature villus cells and proliferation and accelerated migration of cells from the crypts. Expand
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An immunofluorescence test on smears of nasal epithelial cells was used to detect coronavirus infection in the respiratory tract of calves, finding bovine coronav virus isolates belonged to the same serotype despite the source of virus. Expand


Pathology of Neonatal Calf Diarrhea Induced by a Reo-Like Virus
Gross, immunofluorescent, and light microscopic findings in seven gnotobiotic calves inoculated orally with a Reo-like neonatal calf diarrhea virus were compared to findings in three controlExpand
Lesions of the gastrointestinal tract of pigs infected with transmissible gastroenteritis.
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Inflammatory changes in the gastrointestinal tract were minimal at all stages of infection and Goblet cell numbers increased slightly in the recovery stage of the disease and small numbers of mononuclear cells accumulated in the lamina propria during regrowth of the villi. Expand
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