Pathology of Neonatal Calf Diarrhea Induced by a Coronavirus-Like Agent

@article{Mebus1973PathologyON,
  title={Pathology of Neonatal Calf Diarrhea Induced by a Coronavirus-Like Agent},
  author={Charles A. Mebus and Ernest L. Stair and Marvin B. Rhodes and M. J. Twiehaus},
  journal={Veterinary Pathology},
  year={1973},
  volume={10},
  pages={45 - 64}
}
Lesions induced by a bovine coronavirus-like agent were studied in gnotobiotic and colostrum-fed calves using gross, histologic and electron microscopic procedures. Lesions in gnotobiotic calves were present in the colon, mesenteric lymph nodes and in all segments of the small intestine. Calves killed 4 h after the onset of diarrhea had immunofluorescent epithelial cells on the villi of the small intestine and surface of the colon. Calves killed at 44 h had shortened intestinal villi and… Expand
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One-day-old specific-pathogen-free chicks were inoculated intranasally and intraocularly with infectious bronchitis virus (strain G), and six of 30 chicks died of nephritis between days 5-10 postinfection. Expand
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