Pathology of GM2 Gangliosidosis in Jacob Sheep

@article{Porter2011PathologyOG,
  title={Pathology of GM2 Gangliosidosis in Jacob Sheep},
  author={B. Porter and B. C. Lewis and J. Edwards and J. Alroy and B. Zeng and P. Torres and K. N. Bretzlaff and E. Kolodny},
  journal={Veterinary Pathology},
  year={2011},
  volume={48},
  pages={807 - 813}
}
The GM2 gangliosidoses are a group of lysosomal storage diseases caused by defects in the genes coding for the enzyme hexosaminidase or the GM2 activator protein. Four Jacob sheep from the same farm were examined over a 3-year period for a progressive neurologic disease. Two lambs were 6-month-old intact males and 2 were 8-month-old females. Clinical findings included ataxia in all 4 limbs, proprioceptive deficits, and cortical blindness. At necropsy, the nervous system appeared grossly normal… Expand
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