Pathology induced by leukemia inhibitory factor.

  • B Ryffel
  • Published 1993 in International review of experimental pathology


Leukemia inhibitory factor is a glycoprotein growth and differentiation factor with pleiotropic activity. LIF has potent effects on the hematopoietic system, including megakaryocyte progenitor cells. In addition, LIF has bone regeneration activity, induces cachexia and acute-phase response in hepatocytes, and inhibits adipogenesis, to mention the more… (More)


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