Pathology in brainstem regions of individuals with primary dystonia.

  title={Pathology in brainstem regions of individuals with primary dystonia.},
  author={Richard M. Zweig and John C Hedreen and William R Jankel and Manuel F Casanova and Peter J. Whitehouse and Donald L. Price},
  volume={38 5},
Examination of brains from four individuals with the clinical diagnosis of primary dystonia revealed histopathologic abnormalities in two cases. A 29-year-old man with a 15-year history of dystonia musculorum deformans (DMD) had numerous neurofibrillary tangles (NFT) and mild neuronal loss within the locus ceruleus; occasional NFT were also recognized in the substantia nigra pars compacta, pedunculopontine nucleus, and dorsal raphe nucleus. A 68-year-old man with a 35-year history of Meige… CONTINUE READING
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